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Planta Med 1997; 63(6): 558-560
DOI: 10.1055/s-2006-957766
Letters

© Georg Thieme Verlag Stuttgart · New York

Hypoglycemic Effect of trans-Dehydrocrotonin, a Nor-Clerodane Diterpene from Croton cajucara

R. A. F. Farias1 , V. S. N. Rao1 , G. S. B. Viana1 , E. R. Silveira2 , M. A. M. Maciel3 , A. C. Pino3
  • 1Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Cel Nunes de Melo, 1127, Cx. Postal 3157,60430-270 Fortaleza, CE, Brasil
  • 2Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus Pici, Fortaleza, CE, Brasil
  • 3Institute de Química, Universidade Federal do Rio de Janeiro, CT, Bloco A, 21910-240 Rio de Janeiro, RJ, Brasil
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

trans-Dehydrocrotonin (t-DCTN), a 19-nor-clerodane diterpene isolated from the bark of Croton cajucara Benth. (Euphorbiaceae) demonstrated a significant hypoglycemic activity in alloxan-induced diabetic rats but not in normal rats, at oral doses of 25 and 50 mg/kg body weight. The drug also effectively lowered the blood sugar levels in glucose fed normal rats. The hypoglycemic effect of t-DCTN was almost comparable to that produced by glibenclamide (2 mg/kg), a clinically useful drug. The results indicate the antihyperglycemic potential of t-DCTN.