Quantitative Determination of Thapsigargins in Roots and Fruits from Thapsia gymnesica

Anita V. Christiansen; Henrik Paalum; Søren M. Andersen; Antonio Pujadas; Ulla W. Smitt

doi:10.1055/s-2006-957769

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Planta Med 1997; 63(6): 565-567
DOI: 10.1055/s-2006-957769

Letters

Quantitative Determination of Thapsigargins in Roots and Fruits from Thapsia gymnesica

Anita V. Christiansen¹ , Henrik Paalum¹ , Søren M. Andersen² , Antonio Pujadas³ , Ulla W. Smitt¹

¹Department of Medicinal Chemistry, Section of Pharmacognosy, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark
²Department of Organic Chemistry, Danish Technical University, DK-2800 Lyngby, Denmark
³Jardin Botánico de Córdoba, Avda. Linneo, s/n, E-14004 Córdoba, Spain

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Three sesquiterpene lactones, thapsigargin (1), thapsigargicin (2), and nortrilobolid (3), and 6-methoxy-7-geranyloxycoumarin have been isolated from the roots of Thapsia gymnesica (Apiaceae) for the first time. The concentrations of the three thapsigargins in the roots and the fruits have been determined by HPLC analysis.