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Planta Med 1996; 62(1): 28-30
DOI: 10.1055/s-2006-957790
Paper

© Georg Thieme Verlag Stuttgart · New York

Naturally Occurring Somatostatin and Vasoactive Intestinal Peptide Inhibitors. Isolation of Alkaloids from Two Marine Sponges

A. Vassas1 , G. Bourdy2 , J. J. Paillard3 , J. Lavayre3 , M. Païs4 , J. C. Quirion4 , C. Debitus5
  • 1Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, F-34060 Montpellier, France
  • 2ORSTOM, CP 9214, La Paz, Bolivia
  • 3Rhône-Poulenc Rorer S. A., CRVA, BP14, F-94403 Vitry/Seine Cedex, France
  • 4CNRS, Institut de chimie des substances naturelles, F-91198 Gif sur Yvette Cedex, France
  • 5ORSTOM, BP A5, Nouméa, Nouvelle-Calédonie
Further Information

Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

The vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor, SRIF) are important neurotransmitters in a number of basic physiological events. Their disturbances have been reported in many diseases such as cystic fibrosis, impotent man (VIP), Alzheimer's disease, and some tumours (SRIF). Xestospongine B (1), sceptrine (2), and ageliferine (3), three alkaloids isolated from Xestospongia sp. and Agelas novaecaledoniae are reported as somatostatin and VIP inhibitors. The natural products 1, 2, and 3 exhibited a high affinity for somatostatin (IC50 = 12 µM, 0.27 µM, and 2.2 µM, respectively), 2 and 3 showed an affinity for VIP (19.8 µM and 19.2 µM, respectively). Due to the interaction between non-peptidic compounds and somatostatin/VIP receptors, these three alkaloids could be promising agents in the research on natural non-peptidic compounds for therapeutical interventions.

Key words

Porifera - Nepheliospongida - Axinellida - ageliferine - sceptrine - xestospongine B - somatostatin receptor - vasoactive intestinal peptide receptor