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Planta Med 1996; 62(1): 46-50
DOI: 10.1055/s-2006-957795
Paper

© Georg Thieme Verlag Stuttgart · New York

Cyclogossine A: A Novel Cyclic Heptapeptide Isolated from the Latex of Jatropha gossypifolia

S. F. A. J. Horsten1 , A. J. J. van den Berg1 , J. J. Kettenes-van den Bosch2 , B. R. Leeflang3 , R. P. Labadie1
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Universiteit Utrecht, P.O. Box 80082, NL-3508 TB, Utrecht, The Netherlands
  • 2Department of Pharmaceutical Analysis, Faculty of Pharmacy, Universiteit Utrecht, NL-3508 TB, Utrecht, The Netherlands
  • 3Department of NMR Spectroscopy, Bijvoet Center, Faculty of Chemistry, Universiteit Utrecht, NL-3508 TB, Utrecht, The Netherlands
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

From the latex of Jatropha gossypifolia L. (Euphorbiaceae) a novel cyclic heptapeptide was isolated, which we named cyclogossine A. A combination of amino acid analysis, FAB mass spectrometry, and two dimensional 1H-NMR spectroscopy (TOCSY and ROESY) was used to determine the primary structure. The compound was found to contain one glycine, one alanine, one valine, two leucine, one threonine, and one tryptophan residue; its amino acid sequence is: Leu 1 - Ala 2 - Thr 3 - Trp 4 - Leu 5 - Gly 6 - Val 7. The absolute configurations of the amino acids were determined by chiral gas chromatography; all have the L-configuration.

Key words

Jatropha gossypifolia - Euphorbiaceae - cyclogossine A - cyclic peptides