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Planta Med 1996; 62(2): 119-121
DOI: 10.1055/s-2006-957831
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© Georg Thieme Verlag Stuttgart · New York

Induction of Morphological and Functional Differentiation of Human Promyelocytic Leukemia Cells (HL-60) by Tubeimoside 1

Lijian Yu1 , Rundi Ma1 , Tingxi Yu2
  • 1Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xihuamen 20, Xian 710003, People's Republic of China
  • 2Department of Neurophysiology, Xian Medical University, Xian 710061, People's Republic of China
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Two functional parameters evaluated by nitroblue tetrazolium (NBT) dye reduction and zymosan particle phagocytosis and a morphological change assessed by the Wright-Giemsa stain of human promyelocytic leukemia cells (HL-60 cells) were used to determine the extent of HL-60 cell differentiation induced by tubeimoside 1. The results revealed that under the action of tubeimoside 1, HL-60 cells could be induced to differentiate to more mature cells with the functional characteristics of granulocytes. Therefore, tubeimoside 1 could be considered as a promising antileukemic agent for further animal trials.

Key words

Tubeimoside 1 - Bolbostemma paniculatum (Maxim.) Franquet - Cucurbitaceae - induction of cell differentiation - human promyelocytic leukemia cells