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Planta Med 1996; 62(2): 133-136
DOI: 10.1055/s-2006-957835
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© Georg Thieme Verlag Stuttgart · New York

Antiplatelet and Vasorelaxing Actions of Some Aporphinoids

Keh-Shaw Chen1 , Feng-Nien Ko2 , Che-Ming Teng2 , Yang-Chang Wu1
  • 1Graduate Institute of Natural products, Kaohsiung Medical College, Kaohsiung 807, Taiwan, Republic of China
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

A series of aporphines and oxoaporphines was tested for antiplatelet and vasorelaxing actions. (+)-N-Methylactinodaphnine, (-)-norannuradhapurine HBr, xylopine, actinodaphnine, and N-methylnandigerine showed strong inhibition of adenosine 5′-diphosphate (ADP)-induced platelet aggregation. Boldine, (+)-N-methylactinodaphnine, (-)-norannuradhapurine HBr, xylopine, N-acetyllaurolitsine, N-methyllaurotetanine, actinodaphnine, N-methylnandigerine, O-methylbulbocapnine, and liriodenine showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. (+)-N-Methylactinodaphnine, fissoldine HClO4, (-)-norannuradhapurine HBr, xylopine, N-methyllaurotetanine, actinodaphnine, N-methylnandigerine, O-methylbulbocapnine, and liriodenine showed strong inhibition of collagen-induced platelet aggregation. (-)-Norannuradhapurine HBr, xylopine, N-methyllaurotetanine, and actinodaphnine showed strong inhibition of platelet-activating factor (PAF; 1 -O-alkyl-2-acetyl-sn-glycero-3-phosphocholine)-induced platelet aggregation. (+)-N-Methylactinodaphnine, laurotetanine, N-methylactinodaphnine N-oxide, oxoglaucine, boldine, and actinodaphnine showed vasorelaxing action in rat thoracic aorta. The results are discussed on the basis of structure-activity relationships.

Key words

Antiplatelet aggregation - vasorelaxing action - aporphines - oxoaporphines