Cytotoxicity and NMR Spectral Assigments of Ergolide and Bigelovin

Qin Wang; Bing-Nan Zhou; Ren-Wei Zhang; Yong-Yue Lin; Long-Ze Lin; Roberto R. Gil; Geoffrey A. Cordell

doi:10.1055/s-2006-957843

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Planta Med 1996; 62(2): 166-168
DOI: 10.1055/s-2006-957843

Papers

Cytotoxicity and NMR Spectral Assigments of Ergolide and Bigelovin

Qin Wang¹ , Bing-Nan Zhou¹ , Ren-Wei Zhang² , Yong-Yue Lin² , Long-Ze Lin³ , Roberto R. Gil³ , Geoffrey A. Cordell³

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Academia Sinica, Shanghai 200031, People's Republic of China
²Yunnan Institute of Chinese Traditional Medicine, Kunming, People's Republic of China
³Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Two potent cytotoxic sesquiterpene lactones, ergolide (1) and bigelovin (2) were isolated from Inula hupehensis and I. helianthus-aquatica and their structures and NMR data were assigned unambiguously by using a combination of one- and two-dimensional NMR techniques and computer modeling calculations.

Key words

Inula hupehensis - I. helianthus-aquatica - Compositae - sesquiterpene lactones - ergolide - bigelovin - NMR data - cytotoxicity