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Planta Med 1996; 62(2): 173-174
DOI: 10.1055/s-2006-957845
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© Georg Thieme Verlag Stuttgart · New York

Reduction of ACh-lnduced Contraction of Rat Isolated Ileum by Coptisine, (+)-Caffeoylmalic Acid, Chelidonium majus, and Corydalis lutea Extracts1

Sabine C. Boegge2 , Stefanie Kesper3 , Eugen J. Verspohl3 , Adolf Nahrstedt2
  • 2Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität, Hittorfstr. 56, D-48149 Münster, Germany
  • 3Abteilung für Pharmakologie, Institut für Pharmazeutische Chemie der Westfälischen Wilhelms-Universität, Hittorfstr. 58-62, D-48149 Münster, Germany
1 Part of the projected thesis of S. C. Boegge
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1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

The crude extracts of Chelidonium majus and Corydalis lutea were examined for antispasmodic activity against acetylcholine (ACh)-induced contraction on isolated rat ileal smooth muscle. Further, coptisine and caffeoylmalic acid as components of the alkaloid and the hydroxycinnamic acid ester fraction of both plants were similarly investigated. The ACh-induced contraction was found to be antagonized weakly by caffeoylmalic acid (6.9%; 2.5 × 10-5 g/ml organ bath), C. majus extract (12.7%; 2.0 × 10-4 g/ml), and a higher concentration of coptisine (16.5%; 1.0 × 10-5 g/ml) whereas the antispasmodic activity of C. lutea extract reached 45% (2.0 × 10-4 g/ml). Antagonism by papaverine as a positive control amounted to 83.2%.