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Planta Med 1996; 62(2): 175-176
DOI: 10.1055/s-2006-957846
Letters

© Georg Thieme Verlag Stuttgart · New York

Indolopyridoquinazoline Alkaloids with Antiplatelet Aggregation Activity from Zanthoxylum integrifoliolum

Wine-Show Sheen1 , Ian-Lih Tsai1 , Che-Ming Teng2 , Feng-Nien Ko2 , Ih-Sheng Chen1
  • 1School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Republic of China
  • 2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Republic of China
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 µg/ml.