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Planta Med 1996; 62(3): 250-251
DOI: 10.1055/s-2006-957870
Paper

© Georg Thieme Verlag Stuttgart · New York

Anthelmintic Properties of α-Sanshool from Zanthoxylum liebmannianum

Andrés Navarrete1 , 2 , Enrique Hong2
  • 1Laboratorio de Productos Naturales, Area de Química, Universidad Autónoma Chapingo, AP 74, Chapingo Estado de México 56230, México
  • 2Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados Instituto Politécnico Nacional, AP 22026, Mexéco D. F. 14000, México
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

The decoction of the stem bark of Zanthoxylum liebmannianum (Engelm.) P. Wilson (Rutaceae) decreased the count of intestinal nematode eggs in naturally infected sheep. In addition, the chloroformic extract was toxic to Ascaris suum. Fractionation of the organic extract guided by the Ascaris suum lethality test led to the isolation of α-sanshool (LC50 = 83.4 × 10-5 M) as the only active compound. On the other hand, α-sanshool induced tonic-clonic seizures when it was injected intraperitoneally to mice. This finding could be a warning regarding the potential toxicity of this plant.

Key words

α-Sanshool - Zanthoxylum liebmannianum - Rutaceae - Ascaris suum - nematicide - convulsions