Anthelmintic Properties of α-Sanshool from Zanthoxylum liebmannianum

Andrés Navarrete; Enrique Hong

doi:10.1055/s-2006-957870

Planta Medica, Table of Contents

Planta Med 1996; 62(3): 250-251
DOI: 10.1055/s-2006-957870

Paper

Anthelmintic Properties of α-Sanshool from Zanthoxylum liebmannianum

Andrés Navarrete¹ ^, ² , Enrique Hong²

¹Laboratorio de Productos Naturales, Area de Química, Universidad Autónoma Chapingo, AP 74, Chapingo Estado de México 56230, México
²Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados Instituto Politécnico Nacional, AP 22026, Mexéco D. F. 14000, México

Abstract

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Abstract

The decoction of the stem bark of Zanthoxylum liebmannianum (Engelm.) P. Wilson (Rutaceae) decreased the count of intestinal nematode eggs in naturally infected sheep. In addition, the chloroformic extract was toxic to Ascaris suum. Fractionation of the organic extract guided by the Ascaris suum lethality test led to the isolation of α-sanshool (LC₅₀ = 83.4 × 10^-5 M) as the only active compound. On the other hand, α-sanshool induced tonic-clonic seizures when it was injected intraperitoneally to mice. This finding could be a warning regarding the potential toxicity of this plant.

Key words

α-Sanshool - Zanthoxylum liebmannianum - Rutaceae - Ascaris suum - nematicide - convulsions

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