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Planta Med 1996; 62(3): 285-286
DOI: 10.1055/s-2006-957883
Letter

© Georg Thieme Verlag Stuttgart · New York

The Effect of Some 2-Substituted Quinolines Isolated from Galipea longiflora on Plasmodium vinckei petteri Infected Mice

J. C. Gantier1 , A. Fournet, M. H. Munos3 , R. Hocquemiller4
  • 1Laboratoire de Biologie et Contrôle des Organismes Parasites, Faculté de Pharmacie, Université Paris-Sud, Rue J. B. Clément, F-92296 Cedex Châtenay-Malabry, France
  • 2Institut Français de Recherche Scientifique pourle Développement en Coopération (ORSTOM), CC 97, Asuncion, Paraguay
  • 3Laboratoire de Chimie organique, associé au CNRS, Faculté de Pharmacie, rue J. B. Clément, F-92296 Châtenay-Malabry Cedex, France
  • 4Laboratoire de Pharmacognosie, Laboratoire associé au CNRS, Faculté de Pharmacie, Rue J. B. Clément, F-92296 Cedex Châtenay-Malabry, France
Further Information

Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.