Planta Medica, Table of Contents Planta Med 1996; 62(4): 308-313DOI: 10.1055/s-2006-957890 Papers © Georg Thieme Verlag Stuttgart · New York Antifungal Activity from Alpinia galanga and the Competition for Incorporation of Unsaturated Fatty Acids in Cell Growth Hiroyuki Haraguchi1 , Yoshiharu Kuwata1 , Kozo Inada1 , Kazushi Shingu2 , Kazumoto Miyahara2 , Miyoko Nagao3 , Akira Yagi3 1Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan 2Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-01, Japan 3Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan Recommend Article Abstract PDF Download Buy Article Abstract An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8β,17-epoxylabd-12-ene-15,16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation. Key words Alpinia galanga (L.) Willd. - Zingiberaceae - (E)-8β,17-epoxylabd-12-ene-15,16-dial - antifungal activity - cell membrane - unsaturated fatty acids PDF (405 kb)
