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Planta Med 1996; 62(4): 314-316
DOI: 10.1055/s-2006-957891
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© Georg Thieme Verlag Stuttgart · New York

The Action of Ginsenoside Re on Inotropy and Chromotropy of Isolated Atria Prepared from Guinea Pigs

Zhu-Qiu Jin
  • Department of Pharmacology, Hunan Medical University, Changsha 410078, Peoples Republic of China
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Publication History

1995

1996

Publication Date:
04 January 2007 (online)

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Abstract

The effects of ginsenoside Re on atria properties of guinea pigs were studied in vitro. Re decreased dose-dependently the contractile force and frequency of isolated guinea pig atria. The correlation of dose-effects of Re on autorhythmicity and contractility of atria was significant. 4.7 × 10-8M Re prolonged the effective refractory period (ERP) of the left atria. Re non-competitively antagonized the positive chronotropic action of isoprenaline in isolated right atria, PD′2 = 6.37. Re and verapamil non-competitively antagonized the positive inotropic action of CaCl2; the PD′2 value of Re is 6.55; of the PD′2 value of Ver is 5.60.

Key words

Panax ginseng - Araliaceae - ginsenoside Re - atria - inotropy - chronotropy