Planta Medica, Table of Contents Planta Med 1996; 62(4): 314-316DOI: 10.1055/s-2006-957891 Papers © Georg Thieme Verlag Stuttgart · New York The Action of Ginsenoside Re on Inotropy and Chromotropy of Isolated Atria Prepared from Guinea Pigs Zhu-Qiu Jin Department of Pharmacology, Hunan Medical University, Changsha 410078, Peoples Republic of China Recommend Article Abstract PDF Download Buy Article Abstract The effects of ginsenoside Re on atria properties of guinea pigs were studied in vitro. Re decreased dose-dependently the contractile force and frequency of isolated guinea pig atria. The correlation of dose-effects of Re on autorhythmicity and contractility of atria was significant. 4.7 × 10-8M Re prolonged the effective refractory period (ERP) of the left atria. Re non-competitively antagonized the positive chronotropic action of isoprenaline in isolated right atria, PD′2 = 6.37. Re and verapamil non-competitively antagonized the positive inotropic action of CaCl2; the PD′2 value of Re is 6.55; of the PD′2 value of Ver is 5.60. Key words Panax ginseng - Araliaceae - ginsenoside Re - atria - inotropy - chronotropy PDF (199 kb)
