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DOI: 10.1055/s-2006-957893
© Georg Thieme Verlag Stuttgart · New York
Cytotoxic Triterpenoids from the Leaves of Euphorbia pulcherrima
Publication History
1995
1996
Publication Date:
04 January 2007 (online)
Abstract
Two cytotoxic triterpenes have been isolated from Euphorbia pulcherrima. Their structures and stereochemistry have been established from NMR, IR, and El-mass spectroscopy. The compounds were identified as 9,19-cycloart-23-ene-3β,25-diol and 9,19-cycloart-25-ene-3β,24-diol. Cytotoxicity evaluation was performed using Ehrlich ascites tumor cells. While cycloartenol induced no cytotoxic activity against Ehrlich ascites tumor cells, both isolated triterpenes exhibited cell inactivating effects. The IC50 is approximately 7.5 µM, while the IC90 is approximately 13.5 µM for 9,19-cycloart-25-ene-3β,24-diol. The 3β,25-diol compound is 50 % less active.
Key words
Triterpenes - cycloartenol - Euphorbia pulcherrima - Euphorbiaceae - cytotoxicity - Ehrlich ascites