The Cytotoxicity of Psoralidin from Psoralea corylifolia

Yong-Man Yang; Jin-Won Hyun; Min-Sook Sung; Ha-Sook Chung; Byong-Kak Kim; Woo-Hyun Paik; Sam-Sik Kang; Jae-Gahb Park

doi:10.1055/s-2006-957901

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Planta Med 1996; 62(4): 353-354
DOI: 10.1055/s-2006-957901

Letters

The Cytotoxicity of Psoralidin from Psoralea corylifolia

Yong-Man Yang¹ , Jin-Won Hyun¹ , Min-Sook Sung¹ , Ha-Sook Chung³ , Byong-Kak Kim¹ , Woo-Hyun Paik² , Sam-Sik Kang³ , Jae-Gahb Park¹

¹Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, Seoul National University College of Medicine, Seoul 110-744, Korea
²Central Research Institute, Boryung Pharmaceutical Co., Ltd., Kunpo-Si 435-050, Korea
³Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea

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Publication History

1995

1996

Publication Date:
04 January 2007 (online)

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Abstract

A cytotoxic coumestan derivative, psoralidin (1), was isolated from the seed of Psoralea corylifolia. The IC₅₀ values of 1 against SNU-1 and SNU-16 carcinoma cell lines were 53 and 203 µg/ml, respectively, indicating cytotoxic activity against stomach carcinoma cell lines.