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Planta Med 1996; 62(4): 379-381
DOI: 10.1055/s-2006-957915
DOI: 10.1055/s-2006-957915
Letters
© Georg Thieme Verlag Stuttgart · New York
Pretreatment with Tetramethylpyrazine Increases the Release of PGI2 and Decreases TXA2 Release in Isolated Rat Heart
Further Information
Publication History
1995
1996
Publication Date:
04 January 2007 (online)
Abstract
We investigated the release of PGI2 and TXA2 by measuring their stable metabolites of 6-keto-PGF1a and TXB2 in the perfusate in the isolated rat heart after pretreatment with tetramethylpyrazine (TMP). Pretreatment with TMP (12 mg/kg, i.p.) 7 days before preparation produced a significant elevation of 6-keto-PGF1a from 2.30 ± 0.65 ng/min/g of untreated controls to 3.8 ± 0.77 ng/min/g (p < 0.05). Pretreatment with TMP also decreased TXB2 release (p < 0.05 versus control).