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Planta Med 1996; 62(5): 402-404
DOI: 10.1055/s-2006-957925
Paper

© Georg Thieme Verlag Stuttgart · New York

Investigation of Anti-Inflammatory and Antinociceptive Activities of trans-Dehydrocrotonin, a 19-Nor-Clerodane Diterpene from Croton cajucara. Part 1

José Carlos Tavares Carvalho1 , Maria Fernanda Coser Silva2 , Maria Aparecida Medeiros Maciel3 , Angelo da Cunha Pinto3 , Domingos Savio Nunes4 , Ronaldo Mendes Lima4 , Jairo Kenupp Bastos2 , Silvio José Sarti2
  • 1Laboratório de Farmacognosia, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas-UNESP, Rodovia Araraquara-Jaú, km 1, CP 502, Araraquara, São Paulo, CEP 14801-902, Brasil
  • 2Laboratório de Princípios Ativos Naturais, Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Av. do Café s/n, Ribeirão Preto, CEP 14014-903, SP, Brasil
  • 3Instituto de Química, universidade Federal do Rio de Janeiro, CT, Bloco A, Rio de Janeiro, CEP 21910-240, RJ, Brasil
  • 4Departamento de Química, Universidade Federal do Pará, CCEN, Campus Universitário, Belém, CEP 66075-900, PA, Brasil
Further Information

Publication History

1995

1996

Publication Date:
04 January 2007 (online)

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Abstract

The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.

Key words

Croton cajucara - Euphorbiaceae - trans-dehydrocrotonin - 19-nor-clerodane diterpene - anti-inflammatory and antinociceptive