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Planta Med 1996; 62(5): 419-422
DOI: 10.1055/s-2006-957930
Paper

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and Antibacterial Activities of Sesquiterpene Lactones Isolated from Tanacetum praeteritum subsp. praeteritum

Nezhun Gören1 , Herman J. Woerdenbag2 , Candan Bozok-Johansson3
  • 1TÜBITAK, Marmara Research Center, Research Institute for Basic Sciences, Department of Chemistry, TR-41470 Gebze-Kocaeli, Turkey
  • 2Department of Pharmaceutical Biology, University Centre for Pharmacy, University of Groningen, Antonius Deusinglaan 1, NL-9713 AV Groningen, The Netherlands
  • 3University of Marmara, Faculty of Medicine, Department of Microbiology, TR-81326 Haydarpaşa-Istanbul, Turkey
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Publikationsverlauf

1995

1996

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Ten sesquiterpene lactones and one sesquiterpene isolated from Tanacetum praeteritum subsp. praeteritum: 1α,6α-dihydroxyisocostic acid methyl ester (2), 1 α-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epi-tatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3α-hydroxyreynosin (15) were tested against the human lung carcinoma cell line GLC4 and the colorectal cancer cell line COLO 320 as well as against the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida albicans. In addition, two germacranolides tatridin A (16) and tamirin (17) were included in the study. All compounds showed cytotoxic activity (IC50 = 124 µM) but most of them were not effective in the antimicrobial tests.

Key words

Tanacetum praeteritum subsp.praeteritum - Asteraceae - sesquiterpene lactones - bioassay - cytotoxic activity - human colorectal cancer cell line - human small cell lung cancer cell line - antibacterial activity