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Planta Med 1996; 62(5): 427-430
DOI: 10.1055/s-2006-957932
Paper

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and Antioxidative Sesquiterpenoids from Heterotheca inuloides

Isao Kubo1 , Swapan K. Chaudhuri1 , Yumi Kubo1 , Yolanda Sanchez2 , Tetsuya Ogura2 , Takashi Saito3 , Harumi Ishikawa3 , Hiroyuki Haraguchi3
  • 1Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, U.S.A.
  • 2Departamento de Quimica, Universidad Autonoma de Guadalajara, Guadalajara, Mexico
  • 3Faculty of Engineering, Fukuyama University, Higashimura-cho, Fukuyama-shi, Hiroshima 729-02, Japan
Further Information

Publication History

1995

1996

Publication Date:
04 January 2007 (online)

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Abstract

Four sesquiterpenoids, β-caryophyllene, β-caryophyllene 4,5α-oxide, 7-hydroxy-3,4-dihydrocadalin, and 7-hydroxycadalin, isolated from the dried flower of Heterotheca inuloides Cass. (Asteraceae), have been found to exhibit cytotoxic activity against several solid tumor cell lines. Among them, 7-hydroxy-3,4-dihydrocadalin and 7-hydroxycadalin have also been found to inhibit autoxidative and microsomal lipid peroxidation.

Key words

Heterotheca inuloides - Asteraceae - cytotoxic activity - antioxidant activity - sesquiterpenoids - 7-hydroxy-3,4-dihydrocadalin - 7-hydroxycadalin