Inhibitory Effects of Gagaminine, a Steroidal Alkaloid from Cynanchum wilfordi, on Lipid Peroxidation and Aldehyde Oxidase Activity

Dong-Ung Lee; Uk-Seob Shin; Keun Huh

doi:10.1055/s-2006-957953

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000058.xml

Teilen / Bookmarken

Facebook Linkedin Weibo

PDF herunterladen

Planta Med 1996; 62(6): 485-487
DOI: 10.1055/s-2006-957953

Papers

Inhibitory Effects of Gagaminine, a Steroidal Alkaloid from Cynanchum wilfordi, on Lipid Peroxidation and Aldehyde Oxidase Activity

Dong-Ung Lee¹ , Uk-Seob Shin² , Keun Huh²

¹Department of Biochemistry, Dongguk University, Kyongju, Kyongbuk 780-714, Korea
²Department of Pharmacology, College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea

Weitere Informationen

Publikationsverlauf

1996

1996

Publikationsdatum:
04. Januar 2007 (online)

Auch verfügbar auf

als PDF herunterladen Lizenzen und Reprints

Abstract

Gagaminine, a steroidal alkaloid, was isolated for the first time from the root of Cynanchum wilfordi Hemsley (Asclepiadaceae), and its effects on lipid peroxidation and the activity of aldehyde oxidase (EC. 1.2.3.1) were investigated in vitro. This alkaloid suppressed significantly the formation of lipid peroxides in rat liver tissues and potently inhibited the hepatic aldehyde oxidase activity in a dose-dependent manner, with IC₅₀ value of 0.8 µM (0.5 µg/ml). These results indicate that gagaminine is a potent natural antioxidant and may be useful for clinical tests.

Key words

Cynanchum wilfordi Hemsley - Asclepiadaceae - gagaminine - lipid peroxidation - aldehyde oxidase - antioxidant