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Planta Med 1996; 62(6): 512-514
DOI: 10.1055/s-2006-957959
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© Georg Thieme Verlag Stuttgart · New York

Tonkinelin: A Novel Annonaceous Acetogenin from Uvaria tonkinensis

Ying Chen, De Quan Yu
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

Further studies on the root bark of Uvaria tonkinensis Finet et Gagnep. (Annonaceae) led to the isolation of a new Annonaceous acetogenin, tonkinelin (1). The structure of 1 was elucidated on the basis of spectral data and chemical evidence. This compound represents an unusual type of C37 Annonaceous acetogenin, having neither tetrahydrofuran (THF) nor epoxide rings and possessing only a vicinal diol in the hydrocarbon chain. Preliminary pharmacological tests showed that tonkinelin (1) inhibits human leukemia (HL-60) and human colon adenocarcinoma (HCT-8) cell lines in vitro.

Key words

Uvaria tonkinensis - Annonaceae - Annonaceous acetogenins - tonkinelin