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Planta Med 1995; 61(1): 37-40
DOI: 10.1055/s-2006-957995
Paper

© Georg Thieme Verlag Stuttgart · New York

Isolation and Characterization of Platelet-Activating Factor Receptor Binding Antagonists from Biota orientalis

Hyun Ok Yang, Dae-Yeon Suh, Byung Hoon Han
  • Natural Products Research Institute, Seoul National University, 28 Yeunkeun-dong, Chongno-ku, Seoul 110-460, Republic of Korea
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

The leaf extract of Biota orientalis showed potent PAF receptor binding antagonistic activity in our previous screening studies on 234 Korean medicinal plants using rabbit platelet receptor binding tests. The activity-guided purification of the plant extract resulted in the isolation of six compounds, including two active substances. The chemical structures of the compounds isolated were established by chemical and spectrometric analyses as dotriacontane, totarol, 8β-hydroxy-3-oxopimar-15-ene, cedrol (IC50 = 1.3 × 10-5M), pinusolide (IC50 = 2.52 × 10-7M), and 5-hydroxy-7,4′-dimethoxyflavone.

Key words

Biota orientalis - Cupressaceae - platelet-activating factor (PAF) - diterpenoids - flavonoid - dotriacontane - totarol - 8β-hydroxy-3-oxopimar-15-ene - pinusolide - cedrol - 5-hydroxy-7,4′-dimethoxyflavone