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Planta Med 1995; 61(1): 41-44
DOI: 10.1055/s-2006-957996
Paper

© Georg Thieme Verlag Stuttgart · New York

Naturally Occurring Protein Kinase C Inhibitors; II1. Isolation of Oligomeric Stilbenes from Caragana sinica 2

Palaniappan Kulanthaivel3 , William P. Janzen3 , Lawrence M. Ballas3 , Jack B. Jiang3 , Chang-Qi Hu4 , James W. Darges3 , Jan C. Seldin3 , Divann J. Cofield3 , Laurel M. Adams3
  • 3Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717, U.S.A.
  • 4Department of Natural Drugs, School of Pharmacy, Shanghai Medical University, Shanghai, People's Republic of China
1 For part I see: Kulanthaivel, P., Hallock, Y. F., Boros, C, Hamilton, S. M, Janzen, W. P., Ballas, L. M., Loomis, C. R., Jiang, J. B., Katz, B., Steiner, J. R., Clardy, J. (1993) J. Am. Chem. Soc. 115, 64522 This taxon is also referred to as C. chamlagu Lamarck and C. grandifolia Dunn
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1994

1994

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The oligomeric stilbenes (+)-α-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-α-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micro-molar concentrations. (+)-α-Viniferin inhibited kera-tinocyte proliferation (0.4 µM) and free radical release in whole blood (47 µM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.

Key words

Caragana sinica (Buchoz) Rehd - Leguminosae - (+)-α-viniferin - miyabenol C - kobophenol A - oligomeric stilbenes - protein kinase C activity