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Planta Med 1995; 61(1): 45-49
DOI: 10.1055/s-2006-957997
Paper

© Georg Thieme Verlag Stuttgart · New York

Principle of the Bark of Phellodendron amurense to Suppress the Cellular Immune Response: Effect of Phellodendrine on Cellular and Humoral Immune Responses

Hiroshi Mori1 , Masahiro Fuchigami1 , Naoki Inoue1 , Hiroichi Nagai1 , Akihide Koda1 , Itsuo Nishioka2 , Kazuo Meguro3
  • 1Department of Pharmacology, Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502, Japan
  • 2Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan
  • 3Research Institute, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-11, Japan
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Previously we have isolated the quaternary base alkaloids, magnoflorine and phellodendrine, from Phellodendri Cortex (cortex of Phellodendron amurense Rupr., Rutaceae) as the biologically active principles to suppress local graft-versus-host (GvH) reactions in mice. In this paper, we focus on phellodendrine. Phellodendrine suppressed local semi-syngeneic GvH reactions and systemic allogeneic GvH reactions in X-ray irradiated recipient mice. Phellodendrine also suppressed the induction phase of sheep red blood cell (SRBC)-induced delayed type hypersensitivity in mice and tuberculin-induced delayed type hypersensitivity in guinea pigs, but did not suppress the effector phase of these reactions. Surprisingly, phellodendrine, unlike prednisolone and cyclophosphamide, did not affect antibody production in mice to SRBC. Phellodendrine was expected to be a valuable new type of immunosuppressor against the cellular immune response.

Key words

Phellodendron amurense Rupr. - Rutaceae - phellodendrine - cellular immune response - humoral immune response - immunosuppression