Cytotoxic Activity of Amaryllidaceae Alkaloids

B. Weniger; L. Italiano; J.-P. Beck; J. Bastida; S. Bergoñon; C. Codina; A. Lobstein; R. Anton

doi:10.1055/s-2006-958007

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Planta Med 1995; 61(1): 77-79
DOI: 10.1055/s-2006-958007

Letter

Cytotoxic Activity of Amaryllidaceae Alkaloids

B. Weniger¹ , L. Italiano¹ , J.-P. Beck¹ , J. Bastida² , S. Bergoñon² , C. Codina² , A. Lobstein¹ , R. Anton¹

¹Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, B.P. 24, F-67401 Illkirch cedex, France
²Departament de Productes Naturals, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of the tested alkaloids could be observed. Pretazettine (22) was among the most active compound among the 25 tested alkaloids on the Molt4 lymphoid cells, but was inactive against HepG2 hepatoma. On the other hand, lycorenine (11) was found to be the most cytotoxic compound against HepG2 hepatoma, even though it appears to be inactive against Molt4 cells. Almost all of the tested alkaloids showed cytotoxic activity against fibroblastic LMTK cells. Only mesembrenone (25) showed some specificity against Molt4 cells in comparision to LMTK cells.