Direct Enantiomeric Separation of Flavanones by High Performance Liquid Chromatography using Various Chiral Stationary Phases

Paola Ficarra; Rita Ficarra; Carlo Bertucci; Silvana Tommasini; Maria Luisa Calabrò; Domenica Costantino; Maria Carulli

doi:10.1055/s-2006-958041

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Planta Med 1995; 61(2): 171-176
DOI: 10.1055/s-2006-958041

Papers

Direct Enantiomeric Separation of Flavanones by High Performance Liquid Chromatography using Various Chiral Stationary Phases

Paola Ficarra¹ , Rita Ficarra¹ , Carlo Bertucci² , Silvana Tommasini¹ , Maria Luisa Calabrò³ , Domenica Costantino¹ , Maria Carulli¹

¹Pharmaco-Chemical Department, University of Messina, Vill. Annunziata, I-98168 Messina, Italy
²Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, I-56126 Pisa, Italy
³Faculty of Pharmacy, University of Reggio Calabria, Complesso “Barbieri”, I-88021 Roccelletta di Borgia (CZ), Italy

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

The performance of four chiral liquid chromatographic columns (Chiralcel® OA, OJ, OC, OD) was studied with respect to the enantioseparation of flavanones and some derivatives. The effect of mobile phase composition on the retention time and stereo-selectivity was studied. A good enantioseparation (α up to 1.45) was achieved for most of the racemates. Further, the elution order of the enantiomers from the chiral stationary phases has been determined by using a circular dichroism based detection system.

Key words

Column liquid chromatography - chiral stationary phases - flavanones - enantiomeric separation - elution order - circular dichroism detection system