In Vitro and In Vivo Antitumoral Phenanthrenes from the Aerial Parts of Dendrobium nobile

You Hui Lee; Jong Dae Park; Nam In Beak; Shin Il Kim; Byung Zun Ahn

doi:10.1055/s-2006-958043

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Planta Med 1995; 61(2): 178-180
DOI: 10.1055/s-2006-958043

Letters

In Vitro and In Vivo Antitumoral Phenanthrenes from the Aerial Parts of Dendrobium nobile

You Hui Lee¹ , Jong Dae Park¹ , Nam In Beak¹ , Shin Il Kim¹ , Byung Zun Ahn²

¹Laboratory of Natural Products, Korea Ginseng and Tobacco Research Institute, Science Town, Yusung P.O. Box 7, Taejeon 305-345, Korea
²College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea

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1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 × 10⁶ cells of sarcoma 180.