Planta Med 1995; 61(2): 180-182
DOI: 10.1055/s-2006-958044
Letters

© Georg Thieme Verlag Stuttgart · New York

Antifertility Activity of Quassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig Cells In Vitro

Vincent C. O. Njar1 , Taiwo O. Alao1 , Joseph I. Okogun1 , Yinusa Raji2>, Adeyombo F. Bolarinwa2 , Ebere U. Nduka3
  • 1Department of Chemistry, University of Ibadan, Ibadan, Nigeria
  • 2Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
  • 3Postgraduate Institute for Medical Research and Training (PIMRAT), College of Medicine, University of Ibadan, Ibadan, Nigeria
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

Abstract

The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.