Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Rolando Martínez; Víctor Kesternich; Elena Gutierrez; Humberto Dölz; Horacio Mansilla

doi:10.1055/s-2006-958048

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Planta Med 1995; 61(2): 188-189
DOI: 10.1055/s-2006-958048

Letters

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Rolando Martínez¹ , Víctor Kesternich¹ , Elena Gutierrez¹ , Humberto Dölz² , Horacio Mansilla³

¹Instituto de Química, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
²Instituto de Farmacología, Universidad Austral de Chile, Valdivia, Chile
³Consejo Superior de Investigaciones Científicas de España, La Laguna, Tenerife, Spain

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1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [³⁵ S]-methionine uptake without affecting the (methyl-³ H)thymidine and (5,6-³ H)uridine incorporation, when assayed in HeLa cells.