Antiulcer Action and Toxicity of Styrax camporum and Caesalpinia ferrea

Elfriede Marianne Bacchi; Jayme Antonio Aboin Sertié; Nelson Villa; Hilton Katz

doi:10.1055/s-2006-958056

Planta Medica, Inhaltsverzeichnis

Planta Med 1995; 61(3): 204-207
DOI: 10.1055/s-2006-958056

Paper

Antiulcer Action and Toxicity of Styrax camporum and Caesalpinia ferrea

Elfriede Marianne Bacchi¹ , Jayme Antonio Aboin Sertié² , Nelson Villa³ , Hilton Katz⁴

¹Departamento de Farmácia da Faculdade de Ciências Farmacêuticas da Universidade de São Paulo Caixa Postal 66083,CEP 05389-970 São Paulo, SP Brasil
²Laboratório de Farmacologia e Toxicologia de Produtos Naturais, Departamento de Farmacologia, Instituto de Ciências Biomédicas da Universidade de São Paulo,São Paulo, SP Brasil
³Departamento de Histologia e Embriologia, Instituto de Ciências Biomédicas da Universidade de São Paulo, SP Brasil
⁴Faculdades Oswaldo Cruz, São Paulo, SP Brasil

Abstract

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Abstract

Oral administration of Styrax camporum Pohl and Caesalpinia ferrea Martius stem extracts, atropine, and cimetidine, during 15 days, decreased the ulceration size, gastric secretion volume, and increased collagen fibre number of chronic ulcer induced by acetic acid in rats. The pH increased and the concentration of hydrochloric acid decreased after administration of atropine and cimetidine. The ethyl acetate fraction, obtained by chromatography from Styrax camporum Pohl extracts, showed antiulcer activity. The subchronic toxicity was studied during 30 days, through weight variation, water and food consumption and spleen, lung, kidney and liver relative weights. No difference to the control-lot was observed.

key words

Styrax camporum Pohl - Styracaceae - Caesalpinia ferrea Martius - Leguminosae - antiulcer action - toxicity

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