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Planta Med 1995; 61(3): 227-232
DOI: 10.1055/s-2006-958061
Paper

© Georg Thieme Verlag Stuttgart · New York

Biological and Pharmacological Activities and Further Constituents of Hyptis verticillata

Michaela Kuhnt1 , Andrea Pröbstle2 , Horst Rimpler1 , Rudolf Bauer3 , Michael Heinrich1
  • 1Institut für Pharmazeutische Biologie, Albert-Ludwigs-Universität, Schänzlestr. 1, D-79104 Freiburg, Germany
  • 2Institut für Pharmazeutische Biologie, Ludwig-Maximilians-Universität, Karlstr. 29, D-80333 München, Germany
  • 3Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr. 1, D-40225 Düsseldorf, Germany
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Several extracts of Hyptis verticillata and isolated compounds were evaluated for their anti-inflammatory, antibacterial, antisecretory, and cytotoxic properties. The aerial parts yielded (R)-5-hydroxypyrrolidin-2-one and essential oil with the main components α-pinene, β-pinene, and thymol. Spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR, mass, CD) fully characterized (R)-5-hydroxypyrrolidin-2-one, as it was isolated by a bioassay guided fractionation. The essential oil, (R)-5-hydroxypyrrolidin-2-one, as well as the previously isolated rosmarinic acid and dehydropodophyllotoxine contributed to the antibacterial effects of H. verticillata. Furthermore, rosmarinic acid showed significant capillary stabilizing effects. Sideritoflavone inhibited prostaglandin synthase to a significant extent and had antisecretory effects comparable to those of NPPB. The cytotoxicity of the aqueous extract, as demonstrated using KB and HT 29 cell lines, may be of toxicological relevance in cases of internal application.

key words

Hyptis verticillata - Labiatae - (R)-5-hydroxypyrrolidin-2-one - essential oil - antibacterial - anti-inflammatory - antisecretory - cytotoxic - quantification