Download PDF
Planta Med 1995; 61(3): 271-274
DOI: 10.1055/s-2006-958071
Letter

© Georg Thieme Verlag Stuttgart · New York

Chemical and Pharmacological Characterization of Erythrophleum lasianthum Alkaloids

Luisella Verotta1 , Talal Aburjai1 , Colin B. Rogers2 , Paola Dorigo3 , Ildebrando Maragno3 , Daniela Fraccarollo3 , Giovanni Santostasi3 , Rosa Maria Gaion3 , Maura Floreani3 , Francesca Carpenedo3
  • 1Dipartimento di Chimica Organica e Industriale, via Venezian 21, I-20133 Milano, Italy
  • 2Department of Chemistry, University of Durban-Westville, Private Bag X54001, Durban 4000, South Africa
  • 3Dipartimento di Farmacologia, L.go E.Meneghetti 2, I-35131 Padova, Italy
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3β-hydroxynorerythrosuamine (1) and its 3-O-β-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K+-ATPase isolated from bovine cardiac sarcolemmal vesicles.