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Planta Med 1995; 61(4): 297-301
DOI: 10.1055/s-2006-958087
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© Georg Thieme Verlag Stuttgart · New York

Brazilin Stimulates the Glucose Transport in 3T3-L1 Cells

You-Me Kim, Seong-Gon Kim, Lee-Yong Khil, Chang-Kiu Moon
  • College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul, 151-742, Korea
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Publication History

1994

1995

Publication Date:
04 January 2007 (online)

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Abstract

Brazilin {7,11b-dihydrobenz[b]indeno-[1,2-d]pyran-3,6a,9,10(6H)-tetrol} was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.

Key words

Brazilin - insulin signal transduction - 3T3-L1 cells - glucose transport - protein kinase C - insulin receptor autophosphorylation