Biological Activities of Cyanobacteria: Evaluation of Extracts and Pure Compounds

Beatrix S. Falch; Gabriele M. König; Anthony D. Wright; Otto Sticher; Cindy K. Angerhofer; John M. Pezzuto; Heinz Bachmann

doi:10.1055/s-2006-958092

Planta Med 1995; 61(4): 321-328
DOI: 10.1055/s-2006-958092

Papers

Biological Activities of Cyanobacteria: Evaluation of Extracts and Pure Compounds

Beatrix S. Falch¹ , Gabriele M. König¹ ^, ⁴ , Anthony D. Wright¹ , Otto Sticher¹ , Cindy K. Angerhofer² , John M. Pezzuto² , Heinz Bachmann³

¹Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, CH-8057 Zürich, Switzerland
²Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, U.S.A.
³Swiss Federal Institute for Water Resources and Water Pollution Control (EAWAG), CH-8600 Dübendorf, Switzerland
⁴Institute of Pharmaceutical Biology, University of Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig, Germany

Abstract

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Abstract

A total of 80 lipophilic and hydrophilic extracts obtained from 20 samples of cultured freshwater and terrestrial cyanobacteria were investigated for their biological activities. Of all the extracts, 26% exhibited a significant lethal effect against brine shrimp. Out of 54 extracts tested for antimicrobial activity, 78% showed antibacterial and 45% antifungal activities. Of 30 extracts tested for cytotoxicity against KB cells, none was found to be active. Bioassay-guided fractionation of the lipophilic extracts of Fischerella ambigua led to the isolation of three compounds; ambigols A (1) and B (2), and tjipanazole D (3). Compounds 1 and 2 exhibited antibacterial, antifungal, cytotoxic, molluscicidal, anti-inflammatory, and antiviral activities. Tjipanazole D (3) showed moderate antibacterial properties.

Key words

Cyanobacteria - brine shrimp lethality - cytotoxic - antimicrobial - Fischerella ambigua - ambigol A - ambigol B - tjipanazole D

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