Bellidifolin Stimulates Glucose Uptake in Rat 1 Fibroblasts and Ameliorates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Rats

Purusotam Basnet; Shigetoshi Kadota; Mineo Shimizu; Yasumitsu Takata; Masashi Kobayashi; Tsuneo Namba

doi:10.1055/s-2006-958124

Planta Medica, Table of Contents

Planta Med 1995; 61(5): 402-405
DOI: 10.1055/s-2006-958124

Paper

Bellidifolin Stimulates Glucose Uptake in Rat 1 Fibroblasts and Ameliorates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Rats

Purusotam Basnet¹ , Shigetoshi Kadota, Mineo Shimizu² , Yasumitsu Takata³ , Masashi Kobayashi³ , Tsuneo Namba¹

¹Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
²Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
³First Department of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

Abstract

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Abstract

Bellidifolin, isolated from Swertia japonica, was found to be a potent hypoglycemic agent in STZ-induced diabetic rats by both oral and intraperitoneal administration. Bellidifolin significantly lowered the loaded glucose level in normal as well as diabetic rats. Bellidifolin also lowered blood triglyceride levels significantly. It stimulated glucose uptake activity in Rat 1 fibroblasts expressing human insulin receptors.

Key words

Swertia japonica - Gentianaceae - bellidifolin - hypoglycemic activity - glucose uptake activity - Rat 1 fibroblasts

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