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Planta Med 1995; 61(5): 406-408
DOI: 10.1055/s-2006-958125
DOI: 10.1055/s-2006-958125
Paper
© Georg Thieme Verlag Stuttgart · New York
Emodin Pharmacokinetics in Rabbits
Further Information
Publication History
1994
1995
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199505/lookinside/thumbnails/10.1055-s-2006-958125-1.jpg)
Abstract
Administration of emodin to rabbits by i.v. bolus resulted in a serum profile which could be well described by a two-compartment model. The AUC of emodin was 518 µg · min/ml, clearance was 72.3 ml/min, and elimination half life was 227 min which was much longer than that reported in a previous study. Oral administration of emodin resulted in a very low serum concentration. Protein binding of emodin was investigated by the equilibrium dialysis method. Emodin was found to be highly bound (99.6%) to serum protein.
Key words
Anthraquinone - emodin - pharmacokinetics