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Planta Med 1995; 61(5): 425-428
DOI: 10.1055/s-2006-958129
Paper

© Georg Thieme Verlag Stuttgart · New York

Potent Inhibitors of Tyrosinase Activity and Melanin Biosynthesis from Rheum officinale

Koichi Iida1 , Koji Hase2 , Kenji Shimomura1 , Syu Sudo1 , Shigetoshi Kadota2 , Tsuneo Namba2
  • 1Mikimoto Pharmaceutical Co., Ltd., 1425 Kurose-cho, Ise 516, Japan
  • 2Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
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Publication History

1994

1995

Publication Date:
04 January 2007 (online)

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Abstract

Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4′,5-trihydroxystilbene-4′-O-β-D-(2″-O-galloyl)glucopyranoside (1) and 3,4′,5-trihydroxystilbene-4′-O-β-D-(6″-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

Key words

Rheum officinale Baillon - Polygonaceae - tyrosinase inhibitor - melanin biosynthesis inhibitor - stilbenes - B-16 melanoma cells - hyperpigmentation