Planta Medica, Inhaltsverzeichnis Planta Med 1995; 61(5): 425-428DOI: 10.1055/s-2006-958129 Paper © Georg Thieme Verlag Stuttgart · New York Potent Inhibitors of Tyrosinase Activity and Melanin Biosynthesis from Rheum officinale Koichi Iida1 , Koji Hase2 , Kenji Shimomura1 , Syu Sudo1 , Shigetoshi Kadota2 , Tsuneo Namba2 1Mikimoto Pharmaceutical Co., Ltd., 1425 Kurose-cho, Ise 516, Japan 2Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4′,5-trihydroxystilbene-4′-O-β-D-(2″-O-galloyl)glucopyranoside (1) and 3,4′,5-trihydroxystilbene-4′-O-β-D-(6″-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis. Key words Rheum officinale Baillon - Polygonaceae - tyrosinase inhibitor - melanin biosynthesis inhibitor - stilbenes - B-16 melanoma cells - hyperpigmentation PDF (342 kb)
