Download PDF
Planta Med 1995; 61(5): 456-458
DOI: 10.1055/s-2006-958136
Paper

© Georg Thieme Verlag Stuttgart · New York

Determination of Strychnine and Brucine by Capillary Zone Electrophoresis

Yu-Ying Zong, Chun-tao Che
  • Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong
Further Information

Publication History

1995

1995

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A procedure for quantitative estimation of strychnine and brucine in the extracts of Strychnos nux-vomica seeds by capillary zone electrophoresis (CZE) was developed. The buffer solution used was 10 mM phosphate buffer-MeOH (9:1), pH 2.5. The linear calibration range was 0.01-0.15 mg/ml. This method is useful for the qualitative and quantitative determination of strychnine and brucine in plant drug samples, as well as in human plasma.

Key words

Strychnine - brucine - Strychnos nux-vomica L. - Loganiaceae - capillary zone electrophoresis - plant drug analysis