A Cytotoxic Diacetylene from Dendropanax arboreus

William N. Setzer; Todd J. Green; Kylen W. Whitaker; Debra M. Moriarity; Cherie A. Yancey; Robert O. Lawton; Robert B. Bates

doi:10.1055/s-2006-958139

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Planta Med 1995; 61(5): 470-471
DOI: 10.1055/s-2006-958139

Letter

A Cytotoxic Diacetylene from Dendropanax arboreus

William N. Setzer¹ , Todd J. Green¹ , Kylen W. Whitaker¹ , Debra M. Moriarity² , Cherie A. Yancey² , Robert O. Lawton² , Robert B. Bates³

¹Department of Chemistry, The University of Alabama in Huntsville, Huntsville, Alabama 35899, U.S.A.
²Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, Alabama 35899, U.S.A.
³Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, U.S.A.

Further Information

Publication History

1994

1995

Publication Date:
04 January 2007 (online)

Also available at

PDF Download Permissions and Reprints

Abstract

The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by ¹H- and ¹³C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.