Abstract
An efficient method for the addition of trimethylsilylcyanide (TMSCN) to aldehydes using dispersed NbF5 as the catalyst is described. Cyano transfer from TMSCN to aldehydes occurs within 10 minutes at room temperature in the presence of 0.5 mol% of NbF5 under solvent-free conditions giving cyanohydrins in excellent yields of over 95%. These conditions are extremely mild, simple and tolerate various functional groups.
Key words
aldehydes - catalysis - green chemistry - cyanohydrins - solvent-free
References 1 Dr. G. Rajagopal is a Brain Pool Scientist from the Department of Chemistry, BSA Crescent Engineering College, Chennai 600 048, India. He was assisted by a grant from the Korean Federation of Science and Technology Societies and Korea Science and Engineering Foundation.
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