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Synthesis 2007(3): 367-374
DOI: 10.1055/s-2006-958963
DOI: 10.1055/s-2006-958963
PAPER
© Georg Thieme Verlag Stuttgart · New YorkSynthesis of 8-Substituted Pyrazolo[1,5-a]-1,3,5-triazine Derivatives by Palladium-Catalyzed Cross-Coupling Reactions
Further Information
Received
5 September 2006
Publication Date:
21 December 2006 (online)
Publication History
Publication Date:
21 December 2006 (online)
Abstract
8-Substituted pyrazolo[1,5-a]-1,3,5-triazine derivatives 6 were prepared from the corresponding 8-iodopyrazolo[1,5-a]-1,3,5-triazines 5 through palladium-catalyzed cross-coupling reactions. Several bioisosteres of hypoxanthine drugs 2 were then prepared by final nucleophilic aromatic substitution.
Key words
purine - bioisosteres - pyrazolo[1,5-a]-1,3,5-triazine - palladium
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