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Planta Med 1995; 61(6): 519-522
DOI: 10.1055/s-2006-959361
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© Georg Thieme Verlag Stuttgart · New York

Biological and Pharmacological Effects of Pinusolide, a Novel Platelet Activating Factor Antagonist

Hyun Ok Yang1 , 2 , Young Hwa Kang1 , Dae-Yeon Suh1 , Yong Chui Kim1 , Byung Hoon Han1
  • 1Natural Products Research Institute, Seoul National University, 28, Yeunkeun-dong, Chongno-ku, Seoul 110-460, Republic of Korea
  • 2Asan Institute for Life Sciences, Department of Traditional Medicine, 388-1 Poongnap-dong, Songpa-ku, Seoul 138-040, Republic of Korea
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Pinusolide, a potent platelet activating factor (PAF) receptor binding antagonist, inhibited PAF-induced aggregation of rabbit platelets with an IC50 value of 5 µM, whereas no inhibitory effects on the aggregation induced by ADP, thrombin, and collagen were observed. Pinusolide protected the mice from PAF-induced lethality with ED50 values of 1.1 mg/kg, i.v. and 69 mg/kg, p.o. Topically given pinusolide at 2 mg/ear effectively inhibited croton oil induced mouse ear edema. All the pinusolide treated ears recovered to normal healthy appearance in a sharp contrast to totally necrotized untreated ears. These results indicated that pinusolide is a potent and specific PAF antagonist in all experimental models as shown in vitro, in vivo, and in animal tests.

Key words

Platelet activating factor (PAF) antagonist - Biota orientalis - Cupressaceae - pinusolide - PAF-induced lethality - croton oil - topical anti-inflammatory activity