In Vitro Antifungal Activity of Triterpenoid Saponins

A. Favel; M. D. Steinmetz; P. Regli; E. Vidal-Ollivier; R. Elias; G. Balansard

doi:10.1055/s-2006-959407

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Planta Med 1994; 60(1): 50-53
DOI: 10.1055/s-2006-959407

Paper

In Vitro Antifungal Activity of Triterpenoid Saponins

A. Favel¹ , M. D. Steinmetz¹ , P. Regli¹ , E. Vidal-Ollivier² , R. Elias² , G. Balansard²

¹Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, 27 Bvd. J. Moulin, F-13385 Marseille Cedex 5, France
²Laboratoire de Pharmacognosie, Faculté de Pharmacie, 27 Bvd. J. Moulin, F-13385 Marseille Cedex 5, France

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Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. α-Hederin was the most active Compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.

Key words

Triterpenoid saponins - antifungal activity - hederagenin - monodesmosides - Candida glabrata - dermatophytes