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DOI: 10.1055/s-2006-959409
© Georg Thieme Verlag Stuttgart · New York
Anti-Inflammatory Active Polyacetylenes from Bidens campylotheca
Publication History
1993
1993
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199401/lookinside/thumbnails/10.1055-s-2006-959409-1.jpg)
Abstract
The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne (1), heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new Compound, safynol-2-O-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated Compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.
Key words
Bidens campylotheca - Compositae - anti-inflammatory activity - polyacetylenes