Abstract
The effect of the methanolic fraction of Mikania cordata (Burm., B. L. Robinson) root extract was investigated for its possible ulceroprotective
activity in male Sprague-Dawley rats. Oral administration of this extract (50, 100,
or 150 mg/kg) significantly prevented the occurrence of water immersion stress-induced
gastric ulcers in a dose-responsive manner. The extract also dose-dependently inhibited
gastric ulcers induced by ethanol, aspirin, and Phenylbutazone. The ED50 values of the extract in the above four ulcer models were found to be 95.1, 109.7,
125.5, and 136.2 mg/kg, respectively. The volume, acidity, and peptic activity of
the gastric juice in pylorous-ligated rats were not altered upon administration of
the extract (100 or 150 mg/kg) but it significantly and dose-dependently promoted
the gastric mucus secretion in normal as well as stress- and ethanol-induced ulcerated
animals. Based on these results, we conclude that M. cordata root extract possesses antiulcer activity and that the observed activity may be due
to the modulation of defensive factors through an improvement of gastric cytoprotection.
Key words
Mikania cordata
- Compositae - root extract - gastric ulcers - acidity - peptic activity - mucus secretion
- antiulcer activity
