Potent Anti-Tumor Activity and Low Toxicity of Tubeimoside 1 Isolated from Bolbostemma paniculatum

Lijian Yu; Rundi Ma; Yongqing Wang; Hoyoku Nishino

doi:10.1055/s-2006-959459

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Planta Med 1994; 60(3): 204-208
DOI: 10.1055/s-2006-959459

Paper

Potent Anti-Tumor Activity and Low Toxicity of Tubeimoside 1 Isolated from Bolbostemma paniculatum

Lijian Yu¹ , Rundi Ma¹ ^, ³ , Yongqing Wang² , Hoyoku Nishino³

¹Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian 710003, People's Republic of China
²Department of Pharmacy, Shaanxi Provincial Health School, Xian, People's Republic of China
³Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan

Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.

Key words

Bolbostemma paniculatum (Maxim.) Franquet - Cucurbitaceae - tubeimoside 1 - antitumor activity - toxicity