Abstract
The methanol extract of the defatted leaves of Gymnosporia montana was evaluated for hepatoprotective activity by noting its effect on carbon tetrachloride
(CCl4)-induced changes in liver cytoarchitecture and alterations in certain biochemical
parameters. The main parameters studied were transaminase activity, lipid constituents
of serum and liver, orosomucoid level in serum, and liver glycogen and phospholipid
contents. The extract administration led to a significant reversal of the majority
of the altered biochemical parameters. Besides, a significant antagonism of the CCl4-induced changes in the liver cytoarchitecture was also observed. The results confirm
the presence of hepatoprotective activity in the plant material.
Key words
Gymnosporia montana
- Celastraceae - hepatoprotective activity - carbon tetrachloride - hepatotoxicity
