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DOI: 10.1055/s-2006-959516
© Georg Thieme Verlag Stuttgart · New York
Antinociceptive Mechanism of the Actonitine Alkaloids Mesaconitine and Benzoylmesaconine
Publikationsverlauf
1993
1994
Publikationsdatum:
04. Januar 2007 (online)
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Abstract
We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.
Key words
Mesaconitine - benzoylmesaconine - Aconitum carmichaeli - Ranunculaceae - analgesia - brain stem