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DOI: 10.1055/s-2006-959517
© Georg Thieme Verlag Stuttgart · New York
Antinociceptive, Anti-Inflammatory and Antipyretic Effects of Lapidin, a Bicyclic Sesquiterpene*
* A preliminary account of some of these results has been presented at the I Simposio Internacional de Química de Productos Naturales y sus Aplicaciones (8)Publication History
1993
1993
Publication Date:
04 January 2007 (online)
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Abstract
Lapidin, a bicyclic sesquiterpene from Ferula linkii Webb, has been evaluated for antinociceptive, anti-inflammatory, and antipyretic activities in mice and rats. Lapidin, vehicle, or the appropriate reference analgesic and anti-inflammatory compounds (acetylsalicylic acid [ASA] and indomethacin) were injected i.p. The more conspicuous effects of lapidin were: 1) a significant protective effect (17-62%; 2.5-20 mg/kg) towards writhings and stretchings induced by acetic acid in mice; 2) a significant antinociceptive effect on jumping responses in the hot-plate test (120 seconds at 15 mg/kg vs. 40 and 85 seconds in vehicle and ASA-treated mice, respectively); 3) a significant dose-dependent (5-15 mg/kg) antinociceptive effect against mechanical noxious stimuli; 4) a dose-dependent anti-inflammatory effect in the carrageen-an-induced edema which, at the higher dose (20 mg/kg), was comparable (65% inhibition of paw swelling at 3 hours) to that obtained after indomethacin (10 mg/kg); and 5) a moderate antipyretic effect against yeast-induced hyperthermia. Present results demonstrate that lapidin possesses antinociceptive, anti-inflammatory, and less pronounced antipyretic effects comparable to those of classical non-steroid anti-inflammatory drugs, which make it worthy of further investigations as an antinociceptive and anti-inflammatory drug.
Key words
Lapidin - Ferula linkii Webb - Apiaceae - bicyclic sesquiterpenes - antinociceptive - anti-inflammatory - antipyretic compounds